Affiliation:
1. Swedish Institute for Infectious Disease Control and Microbiology and Tumorbiology Centre, Karolinska Institute, Solna, Sweden
Abstract
SUMMARY
The β-chemokines, RANTES, MIP-1α and MIP-1β, have been implicated as being some of the protective factors in the immune response against human immunodeficiency virus (HIV) infection. We have presented data previously indicating that these chemokines also play a role in protective immunity against HIV/SIV infection in macaques. The aim of this study was to investigate the production of β-chemokines in eight cynomolgus macaques vaccinated with non-pathogenic SHIV-4 in relation to protection against pathogenic SIVsm challenge. Four control animals were also included in the study. Two of the vaccinated monkeys were completely protected and one was partially protected against the challenge virus. The monkeys that resisted infectious SIVsm virus challenge showed higher spontaneous β-chemokine production by peripheral blood mononuclear cells and had higher numbers of antigen-induced IFN-γ secreting cells compared to the non-protected animals. Our observations support our previous findings that the genetic background of the host and/or environmental factors are involved in the chemokine production and that β-chemokines contribute to protection against HIV/SIV infection.
Publisher
Oxford University Press (OUP)
Subject
Immunology,Immunology and Allergy
Cited by
21 articles.
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