Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM

Author:

Kerbusch T.,Huitema A. D. R.,Ouwerkerk J.,Keizer H. J.,Mathôt R. A. A.,Schellens J. H. M.,Beijnen J. H.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference21 articles.

1. Pharmacokinetics and metabolism of ifosfamide administered as a continuous infusion in children;Boddy;Cancer Res,1993

2. Pharmacokinetics, metabolism and clinical effects of ifosfamide in breast cancer patients;Boddy;Eur J Cancer,1995

3. Metabolism of oxazaphosphorine;Sladek;Pharmacol Ther,1988

4. Differential activation of cyclophosphamide and ifosfamide by cytochrome P-450 2B and 3 A in human liver microsomes;Chang;Cancer Res,1993

5. Identification of the major human hepatic CYP involved in the activation and N-dechloroethylation of ifosfamide;Walker;Biochem Pharmacol,1994

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