Therapy for Latent HIV-1 Infection: The Role of Histone Deacetylase Inhibitors-Reference-Cited by-同舟云学术

Therapy for Latent HIV-1 Infection: The Role of Histone Deacetylase Inhibitors

Published:2014-08 Issue:4 Volume:23 Page:145-149
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

McManamy Mary E Manson¹,Hakre Shweta²³,Verdin Eric M²³,Margolis David M¹⁴

Affiliation:

1. Department of Medicine, University of North Carolina, Chapel Hill, NC, USA

2. Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, CA, USA

3. Department of Medicine, University of California San Francisco, San Francisco, CA, USA

4. Departments of Microbiology & Immunology and Epidemiology, University of North Carolina, Chapel Hill, NC, USA

Abstract

Persistence of HIV-1 in latently infected CD4+ T-cells prevents eradication in HIV-infected treated patients. Latency is characterized by a reversible silencing of transcription of integrated HIV-1. Several molecular mechanisms have been described which contribute to latency, including the establishment and maintenance of repressive chromatin on the HIV-1 promoter. Histone deacetylation is a landmark modification associated with transcriptional repression of the HIV-1 promoter and inhibition of histone deacetylase enzymes (HDACs) reactivates latent HIV-1. Here, we review the different HDAC inhibitors that have been studied in HIV-1 latency and their therapeutic potential in reactivating latent HIV-1.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.3851/IMP2551

Reference53 articles.

1. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation.

2. Control of HIV Latency by Epigenetic and Non-Epigenetic Mechanisms

3. Human Immunodeficiency Virus (HIV) Latency: The Major Hurdle in HIV Eradication

4. Molecular Understanding of HIV-1 Latency

5. The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation

Cited by 45 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advances in personalized epigenetics in infectious diseases;Personalized Epigenetics;2024

2. Isoform-Selective Versus Nonselective Histone Deacetylase Inhibitors in HIV Latency Reversal;AIDS Research and Human Retroviruses;2022-08-01

3. A transient heritable memory regulates HIV reactivation from latency;iScience;2021-04

4. Exhaustion and senescence of CD4 and CD8 T cells that express co-stimulatory molecules CD27 and CD28 in subjects that acquired HIV by drug use or by sexual route;GERMS;2021-03-15

5. “A transient heritable memory regulates HIV reactivation from latency”;2020-07-02