К вопросу об эффективности плазмонной фототермической терапии экспериментальных опухолей

Author:

Бучарская А.Б.1,Маслякова Г.Н.1,Чехонацкая М.Л.1,Захарова Н.Б.1,Терентюк Г.С.1,Наволокин Н.А.1,Хлебцов Б.Н.2,Хлебцов Н.Г.2,Генин В.Д.34,Башкатов А.Н.34,Генина Э.А.34,Тучин В.В.345

Affiliation:

1. Саратовский государственный медицинский университет им. В.И. Разумовского, Саратов, Россия

2. Институт биохимии и физиологии растений и микроорганизмов РАН, Саратов, Россия

3. Саратовский национальный исследовательский государственный университет им. Н.Г. Чернышевского, Саратов, Россия

4. Национальный исследовательский Томский государственный университет, Томск, Россия

5. Институт проблем точной механики и управления РАН, Саратов, Россия

Abstract

The aim of the study was to study the prognostic factors of the effectiveness of plasmon photothermal therapy (PPT) in rats with transplanted liver cancer based on an assessment of the degree of tumor vascularization. Prior to any exposure, rats with transplanted liver cancer RS-1 underwent a doppler ultrasonography to assess the degree of vascularization of the transplanted tumors. Half of the animals with transplanted tumors were removed from the experiment after dopplerography to determine the content of vascular factors in blood serum by immunoassay and immunohistochemical methods in tumor tissue. After triple intravenous administration of gold nanorods (GNRs) coated with polyethylene glycol at a dose of 0.4 mg/ml, the transplanted tumors were irradiated percutaneously with infrared laser radiation at a wavelength of 808 nm and a thermography of local tumor heating was conducted. After 24 hours, the animals were removed from the experiment and samples of tumor tissue were taken for histological examination. It was found that the accumulation of gold in the tumor tissue and the effectiveness of PPT after repeated intravenous administration of GNRs are determined by the presence of a formed vasculature in the tumor.

Publisher

Ioffe Institute Russian Academy of Sciences

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1. Control of optical heating of a silicon probe using near-field energy transport by localized surface plasmons;Известия Российской академии наук. Серия физическая;2023-12-01

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