Can Apigenin Be an Effective Therapeutic Agent Against Experimental Renal Ischemia-Reperfusion Injury?-Reference-Cited by-同舟云学术

Can Apigenin Be an Effective Therapeutic Agent Against Experimental Renal Ischemia-Reperfusion Injury?

Published:2024-07-31 Issue:2 Volume:12 Page:53-56
ISSN:2147-6470
Container-title:Pediatric Practice and Research
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Author:

Topdağı Ömer¹^ORCID,Güler Mustafa Can²^ORCID,Eraslan Ersen³^ORCID,Ekinci Akdemir Fazile Nur⁴^ORCID,Tanyeli Ayhan²^ORCID,Özbek Şebin Saime²^ORCID,Şebin Engin⁵^ORCID

Affiliation:

1. BAHCESEHIR UNIVERSITY

2. ATATURK UNIVERSITY

3. BANDIRMA ONYEDI EYLUL UNIVERSITY

4. AGRI IBRAHIM CECEN UNIVERSITY

5. UNIVERSITY OF HEALTH SCIENCES, ERZURUM REGION HEALTH RESEARCH CENTER

Abstract

Aim: This study aims to reveal the effects of two doses of apigenin (API) against renal ischemia-reperfusion injury (R I/R). Material and Methods: For this purpose, 5 and 10 mg/kg doses of API were preferred in our study, and the groups were designed as sham, R I/R, 5 mg/kg API, and 10 mg/kg API groups for the implementation of the experimental protocol. In the R I/R model, 1-hour ischemia and 24-hour reperfusion periods were preferred. Oxidative and inflammatory markers were measured biochemically in samples taken at the end of the experiment. Results: Biochemical results showed that oxidative and inflammatory markers increased significantly in the R I/R group, but antioxidant activities decreased significantly. In the 5 and 10 mg/kg API groups, R I/R damage was alleviated considerably, with these markers approaching the sham group values. Conclusion: As a result, the study's results determined that two different doses of API were effective against R I/R-induced kidney damage.

Publisher

Pediatric Practice and Research Journal

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