Use of Heparin-coated Stents in Neurovascular Interventional Procedures: Preliminary Experience with 10 Patients

Author:

Parkinson Richard J.1,Demers Christopher P.2,Adel Joseph G.3,Levy Elad I.4,Sauvageau Eric5,Hanel Ricardo A.3,Shaibani Ali6,Guterman Lee R.7,Hopkins L Nelson6,Batjer H Hunt7,Bendok Bernard R.8

Affiliation:

1. Department of Neurosurgery, St. Vincents Clinic, Sydney, Australia

2. Department of Neurosurgery, Brown Medical School, Providence, Rhode Island

3. Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois

4. Departments of Neurosurgery and Radiology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York

5. Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York

6. Departments of Radiology and Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois

7. Department of Neurosurgery, Buffalo Neurosurgery Group, West Seneca, New York

8. Departments of Neurological Surgery and Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois Toshiba Stroke research Center,School of Medicine and Biomedical Sciences,University at Buffalo,State University of New York

Abstract

Abstract OBJECTIVE: Currently, there is minimal published data on the use of heparin-coated stents in the neurovasculature; however, these stents have a proven clinical record in the treatment of coronary disease. This article details our experience with the safety and technical aspects of stent deployment in the first 10 patients who had heparin-coated stents placed in the intracranial and cervical vasculature and the preliminary follow-up in most cases. METHODS: We retrospectively reviewed the clinical history, intra- and periprocedural data, and imaging for the patients who received heparin-coated stents in the cervical and intracranial vasculature for cerebrovascular disease between October 2002 and October 2003. RESULTS: Thirteen heparin-coated stents were placed in 10 patients. Seven out of the 10 patients had heparin-coated stents placed in the posterior circulation; the remaining three patients had stents placed in the anterior circulation. Four patients had stents placed intracranially. There was no acute or subacute in-stent thrombosis and no procedure-related complications. Follow-up was performed on most patients, with no clinical symptoms attributable to restenosis in any patient. CONCLUSION: This small series suggests that heparin-coated stents are safe for use in the treatment of cervical and intracranial atherosclerotic disease. Longer-term follow-up is needed to study the heparin coating effect on in-stent restenosis rates and to assess the long-term durability and clinical efficacy of this stent. The use of drug-coated stents in the cerebrovascular circulation is an area that warrants further investigation.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Neurology (clinical),Surgery

Reference121 articles.

1. Study results;A Stenting of Symptomatic Atherosclerotic Lesions in the Vertebral or Intracranial Arteries (SSYLVIA);Stroke,2004

2. Drug-eluting stents for the treatment of intracranial atherosclerosis: Initial experience and midterm angiographic follow-up;Abou-Chebl,2005

3. A reappraisal of angioplasty and stenting for the treatment of vertebral origin stenosis;Albuquerque;Neurosurgery,2003

4. Stenting of symptomatic stenosis of the intracranial internal carotid artery;Al-Mubarak;AJNR Am J Neuroradiol,1998

5. Effects of stent coating on platelets and endothelial cells after intracoronary stent implantation;Atalar;Clin Cardiol,2001

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