Local Control of Recurrent Clival and Sacral Chordoma after Interstitial Irradiation with Iodine-125: New Techniques for Treatment of Recurrent or Unresectable Chordomas

Author:

Kumar Pradeep P.1,Good Roger R.1,Skultety F. Miles2,Leibrock Lyal G.2

Affiliation:

1. Division of Radiation Oncology, University of Nebraska College of Medicine, Omaha, Nebraska

2. Department of Neurosurgery, University of Nebraska College of Medicine, Omaha, Nebraska

Abstract

Abstract Using new 125I brachytherapy techniques, we were able to deliver safely a tumor volume dose of 16,000 rads to a previous irradiated, large, recurrent sacral chordoma by means of the intraoperative interstitial implantation of 229 low activity 125I seeds and 40,000 rads to a previously irradiated, small, recurrent clival chordoma by means of the transnasal needle implantation of two high activity 125I seeds. Iodine-125 brachytherapy was followed by regression of tumor, lessening of symptoms, and bony recalcification in both cases. (Neurosurgery 22:479-483, 1988)

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Neurology (clinical),Surgery

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