Chronic Disseminated Intravascular Coagulation and Metastatic Brain Tumor: A Case Report and Review of the Literature

Author:

Sawaya Raymond1,Donlon Jerome A.2

Affiliation:

1. National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland

2. Clinical Center, National Institutes of Health, Bethesda, Maryland

Abstract

Abstract A patient who had a primary lung carcinoma in remission but had a solitary metastatic lesion to the cerebellum was referred to the neurosurgery service. He was noted to be thrombocytopenic, and further hemostatic evaluation revealed chronic disseminated intravascular coagulation. He was treated with heparin and platelet transfusions. Although the fibrinogen levels improved, the thrombocytopenia persisted. Four weeks after admission, repeat chest x-ray films and tomograms indicated progressing metastatic nodules. A review of the literature reveals a variety of hemostatic defects associated with tumor metastatic to the brain. This current case indicates the need for careful hemostatic evaluation in all patients with brain lesions.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Neurology (clinical),Surgery

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