Treatment of Malignant Gliomas with Surgery, Intra-arterial Infusions of 1-(2-Hydroxyethyl)chloroethylnitrosourea, and Radiation Therapy: A Phase II Study-Reference-Cited by-同舟云学术

Treatment of Malignant Gliomas with Surgery, Intra-arterial Infusions of 1-(2-Hydroxyethyl)chloroethylnitrosourea, and Radiation Therapy: A Phase II Study

Published:1990-08-01 Issue:2 Volume:27 Page:231-234
ISSN:1524-4040
Container-title:Neurosurgery
language:en
Short-container-title:

Author:

Fauchon François¹,Davila Luis²,Chatellier Gilles³,Fohanno Denis⁴,Philippon Jacques⁴,Rey Alain⁵,Chiras Jacques²,Poisson Michel⁶,Delattre Jean Yves¹,Delattre Jean Yves⁶

Affiliation:

1. Departments of Radiation Therapy, Hôpital Beaujon, Paris, France

2. Neuroradiology Hôpital Beaujon, Paris, France

3. Biostatisties Hôpital Beaujon, Paris, France

4. Neurosurgery Hôpital Beaujon, Paris, France

5. Groupe Hospitalier Pitié-Salpêtrière, and Department of Neurosurgery, Hôpital Beaujon, Paris, France

6. Neurology Hôpital Beaujon, Paris, France

Abstract

Abstract Forty patients with malignant supratentorial gliomas were treated with surgery, intra-arterial infusions of 1-(2-hydroxyethyl) chloroethylnitrosourea, and radiation therapy. The median duration of survival was 12 months: it differed according to the histological subtype (over 30 months for patients with anaplastic astrocytomas or anaplastic oligoden-droglioma and 10.5 months for glioblastoma; P= 0.0025). Serious complications of monocular blindness and leukoencephalopathy were observed in four patients (10%).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Neurology (clinical),Surgery

Link

http://academic.oup.com/neurosurgery/article-pdf/27/2/231/32547792/00006123-199008000-00010.pdf

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