5-Fluorouracil and 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) Followed by Hydroxyurea, Misonidazole, and Irradiation for Brain Stem Gliomas: A Pilot Study of the Brain Tumor Research Center and the Childrens Cancer Group-Reference-Cited by-同舟云学术

5-Fluorouracil and 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) Followed by Hydroxyurea, Misonidazole, and Irradiation for Brain Stem Gliomas: A Pilot Study of the Brain Tumor Research Center and the Childrens Cancer Group

Published:1984-06-01 Issue:6 Volume:14 Page:679-681
ISSN:0148-396X
Container-title:Neurosurgery
language:en
Short-container-title:

Author:

Levin Victor A.¹,Edwards Michael S.¹,Wara William M.²,Allen Jeffrey³,Ortega Jorge⁴,Vestnys Pamela¹

Affiliation:

1. Brain Tumor Research Center, Department of Neurological Surgery, University of California Medical School, San Francisco, California

2. Department of Radiation Oncology, Childrens Hospital of Los Angeles, Los Angeles, California

3. Department of Neurology, Childrens Hospital of Los Angeles, Los Angeles, California

4. Memorial-Sloan Kettering Hospital, New York, New York Department of Hematology-Oncology, Childrens Hospital of Los Angeles, Los Angeles, California

Abstract

Abstract Twenty-eight evaluable children with the diagnosis of brain stem glioma were treated with 5-fluorouracil and CCNU before posterior fossa irradiation (5500 rads); during irradiation, the children received hydroxyurea and misonidazole, The treatment was well tolerated, and minimal toxicity was produced. The median relapse-free survival was 32 weeks, and the median survival was 44 weeks. Analysis of covariates showed that, in patients between the ages of 2 and 19 years, survival was longest in the older children (P < 0.02). Tumor histology, sex, extent of operation (if any), Karnofsky score, and radiation dose did not correlate with survival.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Clinical Neurology,Surgery

Link

http://academic.oup.com/neurosurgery/article-pdf/14/6/679/32543125/00006123-198406000-00006.pdf

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