Trimethoprim and Sulfamethoxazole are Selective Inhibitors of CYP2C8 and CYP2C9, Respectively

Author:

Wen Xia,Wang Jun-Sheng,Backman Janne T.,Laitila Jouko,Neuvonen Pertti J.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference25 articles.

1. In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines.;Back;Br J Clin Pharmacol,1988

2. Distribution of trimethoprim-sulfamethoxazole in tissues of rhesus monkeys.;Craig;J Infect Dis,1973

3. N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes.;Cribb;Drug Metab Dispos,1995

4. A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.;Dierks;Drug Metab Dispos,2001

5. Dollery C (1999) Sulfamethoxazole and trimethoprim combination. in Therapeutic Drugs, ed Dollery C (Churchill Livingstone, Edinburgh), pp S136–S140.

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