Sequential Metabolism of AMG 487, a Novel CXCR3 Antagonist, Results in Formation of Quinone Reactive Metabolites That Covalently Modify CYP3A4 Cys239 and Cause Time-Dependent Inhibition of the Enzyme-Reference-Cited by-同舟云学术

Sequential Metabolism of AMG 487, a Novel CXCR3 Antagonist, Results in Formation of Quinone Reactive Metabolites That Covalently Modify CYP3A4 Cys239 and Cause Time-Dependent Inhibition of the Enzyme

Published:2012-04-19 Issue:7 Volume:40 Page:1429-1440
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Henne Kirk R.,Tran Thuy B.,VandenBrink Brooke M.,Rock Dan A.,Aidasani Divesh K.,Subramanian Raju,Mason Andrew K.,Stresser David M.,Teffera Yohannes,Wong Simon G.,Johnson Michael G.,Chen Xiaoqi,Tonn George R.,Wong Bradley K.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference47 articles.

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4. Role of Quinones in Toxicology

5. Initiation of cancer and other diseases by catechol ortho-quinones: a unifying mechanism

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