Compartmental and Enzyme Kinetic Modeling To Elucidate the Biotransformation Pathway of a Centrally Acting Antitrypanosomal Prodrug-Reference-Cited by-同舟云学术

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Compartmental and Enzyme Kinetic Modeling To Elucidate the Biotransformation Pathway of a Centrally Acting Antitrypanosomal Prodrug

Published:2012-12-06 Issue:2 Volume:41 Page:518-528
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Generaux Claudia N.,Ainslie Garrett R.,Bridges Arlene S.,Ismail Mohamed A.,Boykin David W.,Tidwell Richard R.,Thakker Dhiren R.,Paine Mary F.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference31 articles.

1. In vitrometabolism of an orally activeO-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis

2. Metabolites of the phenylurea herbicides chlorotoluron, diuron, isoproturon and linuron produced by the soil fungus Mortierella sp.

3. Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes

4. Human African trypanosomiasis: pharmacological re-engagement with a neglected disease

5. Parameters influencing biotransformation rates of phenylurea herbicides by soil microorganisms;Berger;Pestic Biochem Physiol,1998

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5. Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis;PLoS Neglected Tropical Diseases;2013-06-06

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