Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation-Reference-Cited by-同舟云学术

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Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation

Published:2016-01-27 Issue:4 Volume:44 Page:554-559
ISSN:1521-009X
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metabolism and Disposition

Author:

Shi J.,Wang X.,Nguyen J.,Wu A. H.,Bleske B. E.,Zhu H.-J.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference28 articles.

1. Species Difference of Esterase Expression and Hydrolase Activity in Plasma

2. Effects of age and sex on the pharmacokinetics of LCZ696, an angiotensin receptor neprilysin inhibitor

3. Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

4. A Possible Mechanism for the Differences in Efficiency and Variability of Active Metabolite Formation from Thienopyridine Antiplatelet Agents, Prasugrel and Clopidogrel

5. Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs

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