Metabolism of the Endocrine Disruptor Pesticide-Methoxychlor by Human P450s: Pathways Involving a Novel Catechol Metabolite

Author:

Hu Yiding,Kupfer David

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference37 articles.

1. Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16[alpha ]-hydroxylation of 17[beta ]-estradiol

2. Mechanism of induction of cytochrome P450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system.;Blizard;Drug Metab Dispos,2001

3. Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants.;Bulger;Mol Pharmacol,1985

4. Interactions of methoxychlor, methoxychlor base-soluble contaminant and 2,2-bis-(p-hydroxy phenyl)-1,1,1-trichloroethane with rat uterine estrogen receptor.;Bulger;J Toxicol Environ Health,1978

5. Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation

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