Distribution of STI-571 to the Brain Is Limited by P-Glycoprotein-Mediated Efflux

Author:

Dai HaiQing,Marbach Peter,Lemaire Michel,Hayes Michael,Elmquist William F.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference43 articles.

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2. Quantification of the anti-leukemia drug STI571 (Gleevec) and its metabolite (CGP 74588) in monkey plasma using a semi-automated solid phase extraction procedure and liquid chromatography-tandem mass spectrometry.;Bakhtiar;J Pharm Biomed Anal,2002

3. P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

4. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.;Buchdunger;J Pharmacol Exp Ther,2000

5. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.;Buchdunger;Cancer Res,1996

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