Divergent Proarrhythmic Potential of Macrolide Antibiotics Despite Similar QT Prolongation: Fast Phase 3 Repolarization Prevents Early Afterdepolarizations and Torsade de Pointes

Author:

Milberg Peter,Eckardt Lars,Bruns Hans-Jürgen,Biertz Julia,Ramtin Shahram,Reinsch Nico,Fleischer Dirk,Kirchhof Paulus,Fabritz Larissa,Breithardt Günter,Haverkamp Wilhelm

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference28 articles.

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2. Cellular and Ionic Mechanisms Underlying Erythromycin-Induced Long QT Intervals and Torsade de Pointes

3. Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes.;Daleau;Angiology,1995

4. La tachycardie ventriculaire à deux foyers opposés variables.;Dessertenne;Arch Mal Coeur,1966

5. Electrophysiologic Characterization of the Antipsychotic Drug Sertindole in a Rabbit Heart Model of Torsade de Pointes: Low Torsadogenic Potential Despite QT Prolongation

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