1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane Methanesulfonate (SC-435), an Ileal Apical Sodium-Codependent Bile Acid Transporter Inhibitor Alters Hepatic Cholesterol Metabolism and Lowers Plasma Low-Density Lipoprotein-Cholesterol Concentrations in Guinea Pigs

Author:

West Kristy L.,Ramjiganesh Tripurasundari,Roy Suheeta,Keller Bradley T.,Fernandez Maria Luz

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

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1. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets;Signal Transduction and Targeted Therapy;2024-04-26

2. Uptake Transporters;Reference Module in Biomedical Sciences;2023

3. Targeting bile acid signaling for the treatment of liver diseases: From bench to bed;Biomedicine & Pharmacotherapy;2022-08

4. The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease;Journal of Medicinal Chemistry;2020-01-13

5. Gluco-Metabolic Effects of Pharmacotherapy-Induced Modulation of Bile Acid Physiology;The Journal of Clinical Endocrinology & Metabolism;2019-10-20

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