Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase IIβInteraction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity

Author:

Kollárová-Brázdová PetraORCID,Jirkovská AnnaORCID,Karabanovich GalinaORCID,Pokorná ZuzanaORCID,Bavlovič Piskáčková HanaORCID,Jirkovský EduardORCID,Kubeš JanORCID,Lenčová-Popelová OlgaORCID,Mazurová YvonaORCID,Adamcová MichaelaORCID,Skalická VeronikaORCID,Štěrbová-Kovaříková PetraORCID,Roh JaroslavORCID,Šimůnek TomášORCID,Štěrba MartinORCID

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference45 articles.

1. Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations

2. Cancer Therapy–Related Cardiac Dysfunction and Heart Failure

3. Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite;Bures;Toxicology,2017

4. Creighton AM (1976) inventor, National Research Development Corporation, assignee. Bis diketopiperazines. Patent US3941790A. 1976 Mar 2.

5. Creighton AM (1992) inventor, National Research Development Corporation, assignee. Cardioprotective bis-dioxopiperazines. Patent GB2245832A. 1992 Jan 15.

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