Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies-Reference-Cited by-同舟云学术

Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies

Published:2020-07-06 Issue:3 Volume:374 Page:469-478
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Ferreira W.A.,Chweih H.,Lanaro C.,Almeida C.B.,Brito P.L.,Gotardo E.M.F.,Torres L.,Miguel L.I.,Franco-Penteado C.F.,Leonardo F.C.,Garcia F.,Saad S.T.O.,Frenette P.S.^ORCID,Brockschnieder D.,Costa F.F.,Stasch J.P.,Sandner P.,Conran N.^ORCID

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference52 articles.

1. Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment

2. Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice

3. Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea

4. High expression of the cGMP-specific phosphodiesterase, PDE9A, in sickle cell disease (SCD) and the effects of its inhibition in erythroid cells and SCD neutrophils

5. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

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3. Soluble guanylate cyclase stimulators and activators: new horizons in the treatment of priapism associated with sickle cell disease;Frontiers in Pharmacology;2024-02-07

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