The Positive Allosteric Modulator ofα2/3-Containing GABAAReceptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury-Reference-Cited by-同舟云学术

The Positive Allosteric Modulator ofα2/3-Containing GABAAReceptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury

Published:2019-11-06 Issue:1 Volume:372 Page:83-94
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Witkin Jeffrey M.,Li Guanguan,Golani Lalit K.,Xiong Wenhui,Smith Jodi L.,Ping Xingjie,Rashid Farjana,Jahan Rajwana,Cerne Rok,Cook James M.,Jin Xiaoming

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference64 articles.

1. GABAA Receptor Subtype-Selective Modulators. I. α2/α3-Selective Agonists as Non-Sedating Anxiolytics

2. Reducing Abuse Liability of GABAA/Benzodiazepine Ligands via Selective Partial Agonist Efficacy at α1 and α2/3 Subtypes

3. Epileptogenic networks and drug-resistant epilepsy: present and future perspectives of epilepsy research-utility for the epileptologist and the epilepsy surgeon;Banerjee;Ann Indian Acad Neurol,2014

4. Validation of a preclinical drug screening platform for pharmacoresistant epilepsy;Barker-Haliski;Neurochem Res,2017

5. Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mechanistic and therapeutic relationships of traumatic brain injury and γ-amino-butyric acid (GABA);Pharmacology & Therapeutics;2024-04

2. BAER‐101, a selective potentiator of α2‐ and α3‐containing GABA_A receptors, fully suppresses spontaneous cortical spike‐wave discharges in Genetic Absence Epilepsy Rats from Strasbourg (GAERS);Drug Development Research;2024-02-21

3. New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy;ACS Chemical Neuroscience;2024-01-04

4. KRM–II–81 suppresses epileptifom activity across the neural network of cortical tissue from a patient with pharmacoresistant epilepsy;Heliyon;2024-01

5. Identification of New Antiseizure Medication Candidates in Preclinical Animal Studies;International Journal of Molecular Sciences;2023-08-24