(E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-2′-(methanesulfonyl)-4-methylvalerohydrazide (Ro 32-7315), a Selective and Orally Active Inhibitor of Tumor Necrosis Factor-α Convertase

Author:

Beck G.,Bottomley G.,Bradshaw D.,Brewster M.,Broadhurst M.,Devos R.,Hill C.,Johnson W.,Kim H.-J.,Kirtland S.,Kneer J.,Lad N.,Mackenzie R.,Martin R.,Nixon J.,Price G.,Rodwell A.,Rose F.,Tang J.-P.,Walter D. S.,Wilson K.,Worth E.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference27 articles.

1. New α-Substituted Succinate-Based Hydroxamic Acids as TNFα Convertase Inhibitors

2. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.;Birchall;J Pharmacol Exp Ther,1994

3. Matrix metalloproteinases: a review.;Birkedal-Hansen;Crit Rev Oral Biol,1993

4. Interleukin-1 and tumor necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1α (1988);Buchan;Clin Exp Immunol,1988

5. The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-α (TNF-α) and TNF-α receptors during human endotoxemia.;Dekkers;Blood,1999

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