LCAT Enzyme Replacement Therapy Reduces LpX and Improves Kidney Function in a Mouse Model of Familial LCAT Deficiency

Author:

Vaisman Boris L.ORCID,Neufeld Edward B.,Freeman Lita A.,Gordon Scott M.,Sampson Maureen L.,Pryor Milton,Hillman Emily,Axley Milton J.,Karathanasis Sotirios K.,Remaley Alan T.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference45 articles.

1. Ahsan L Ossoli AF Freeman LA Vaisman B Amar MJ Shamburek RD Remaley AT (2014) Role of lecithin: cholesterol acyltransferase in HDL metabolism and atherosclerosis, in The HDL Handbook: Biological Functions and Clinical Implications ( Komoda T ed) pp 159–194, Academic Press, London.

2. Enzyme Replacement for Lysosomal Diseases

3. Overexpression of human lecithin:cholesterol acyltransferase in cholesterol-fed rabbits: LDL metabolism and HDL metabolism are affected in a gene dose-dependent manner;Brousseau;J Lipid Res,1997

4. Collins HL Vaisman BL Adelman SJ Remaley AT Karathanasis S (2016) Acute Lecithin: Cholesterol Acyltransferase Infusion Increases Whole Body Macrophage-specific Cholesterol Efflux in Lecithin:cholesterol Acyltransferase Deficient Human ApoA-I Transgenic Mice. American Heart Association Scientific Sessions #565, New Orleans, LA, November 12-16, 2016.

5. Secretion of lipoprotein-X by perfused livers of rats with cholestasis.

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