Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor-Reference-Cited by-同舟云学术

Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor

Published:2018-08-03 Issue:1 Volume:367 Page:147-154
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Marro Martin L.,Patterson Andrew W.,Lee Lac,Deng Lin,Reynolds Aimee,Ren Xianglin,Axford Laura,Patnaik Anup,Hollis-Symynkywicz Micah,Casson Nigel,Custeau Dominique,Ames Lisa,Loi Sally,Zhang Lihe,Honda Toshiyuki,Blank Jutta,Harrison Tyler J.,Papillon Julien P. N.,Hamann Lawrence G.,Marcinkeviciene Jovita,Regard Jean B.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference29 articles.

1. Myeloperoxidase and Plasminogen Activator Inhibitor 1 Play a Central Role in Ventricular Remodeling after Myocardial Infarction

2. Increased atherosclerosis in myeloperoxidase-deficient mice

3. Transgenic mice express human MPO −463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in −463G males

4. Late Intervention with a Myeloperoxidase Inhibitor Stops Progression of Experimental Chronic Obstructive Pulmonary Disease

5. Evaluation of Enzyme Inhibitors in Drug Discovery

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5. Discovery of a Novel, Highly Potent and Orally Bioavailable Pyrrolidinone Indole Series of Irreversible Myeloperoxidase (MPO) Inhibitors;SSRN Electronic Journal;2022