Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin

Author:

Dabydeen Donnette A.,Burnett James C.,Bai Ruoli,Verdier-Pinard Pascal,Hickford Sarah J. H.,Pettit George R.,Blunt John W.,Munro Murray H. G.,Gussio Rick,Hamel Ernest

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference39 articles.

1. Total synthesis of halichondrin B and norhalichondrin B

2. Alley MC, Smith AC, Donohoe SJ, Schweikart KM, Newman DJ, and Tomaszewski JE (2005) Comparison of the relative efficacies and toxicities of halichondrin B analogues, in Proceedings of the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics; 2005 Nov 14-18; Philadelphia, PA, abstract C230, pp 257, American Association for Cancer Research, Philadelphia, PA.

3. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

4. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

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