Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent

Author:

Millner Lori M.,Doll Mark A.,Cai Jian,States J. Christopher,Hein David W.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference41 articles.

1. Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro;Adam;Mol Cancer Res,2003

2. Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells

3. Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1;Barker;Pharmacogenet Genomics,2006

4. Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer;Bell;Cancer Res,1995

5. 2-Amino-3,8-Dimethylimidazo-[4,5-f]Quinoxaline-Induced DNA Adduct Formation and Mutagenesis in DNA Repair-Deficient Chinese Hamster Ovary Cells Expressing Human Cytochrome P4501A1 and Rapid or Slow Acetylator N-Acetyltransferase 2

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