Biocatalytic Synthesis and Structure Elucidation of Cyclized Metabolites of the Deacetylase Inhibitor Panobinostat (LBH589)-Reference-Cited by-同舟云学术

Biocatalytic Synthesis and Structure Elucidation of Cyclized Metabolites of the Deacetylase Inhibitor Panobinostat (LBH589)

Published:2012-02-16 Issue:5 Volume:40 Page:1041-1050
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Fredenhagen Andreas,Kittelmann Matthias,Oberer Lukas,Kuhn Anton,Kühnöl Jürgen,Délémonté Thierry,Aichholz Reiner,Wang Ping,Atadja Peter,Shultz Michael D.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference31 articles.

1. Melatonin: structural characterization of its non-enzymatic mono-oxygenate metabolite

2. Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges

3. Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system inEscherichia coli

4. Anticancer activities of histone deacetylase inhibitors

5. Mechanistic Studies on a P450-Mediated Rearrangement of BMS-690514: Conversion of a Pyrrolotriazine to a Hydroxypyridotriazine

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