Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity-Reference-Cited by-同舟云学术

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Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity

Published:2011-09-30 Issue:1 Volume:40 Page:139-150
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Castellino Stephen,O'Mara Michael,Koch Kevin,Borts David J.,Bowers Gary D.,MacLauchlin Christopher

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference28 articles.

1. Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects

3. Risk Factors for Idiosyncratic Drug-Induced Liver Injury

4. Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

5. Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

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1. EGFR-ErbB2 dual kinase inhibitor lapatinib decreases autoantibody levels and worsens renal disease in Interferon α-accelerated murine lupus;International Immunopharmacology;2024-10

2. Use of Structural Alerts for Reactive Metabolites in the Application SpotRM;Chemical Research in Toxicology;2024-08-01

3. Bioactivation and reactivity research advances – 2023 year in review;Drug Metabolism Reviews;2024-07-17

4. Hepatotoxicity of Anti-cancer Drugs;Interdisciplinary Cancer Research;2024

5. The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib;Toxicological Sciences;2023-10-03

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