In Vitro Metabolism of Irosustat, a Novel Steroid Sulfatase Inhibitor: Interspecies Comparison, Metabolite Identification, and Metabolic Enzyme Identification

Author:

Ventura Verònica,Solà Josep,Celma Carles,Peraire Concepción,Obach Rosendo

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference22 articles.

1. Bohnert T Gan LS (2010) The role of drug metabolism in drug discovery, in Enzyme Inhibition in Drug Discovery and Development: The Good and the Bad ( Lu C Li AP eds) pp 91–176, John Wiley & Sons, Hoboken, NJ.

2. Steroid metabolism in breast cancer;Foster;Minerva Endocrinol,2008

3. In vivo Efficacy of STX213, A Second-Generation Steroid Sulfatase Inhibitor, for Hormone-Dependent Breast Cancer Therapy

4. Gomez-Lechon MJ Donato MT Ponsoda X Jover R Castell JV (1992) Experimental in vitro models to evaluate hepatotoxicity, in In Vitro Alternatives to Animal Pharmaco-toxicology ( Castell JV Gomez-Lechon MJ eds) pp 92–107, Farmaindustria, Madrid.

5. Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates

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