Inhibition of P-Glycoprotein Leads to Improved Oral Bioavailability of Compound K, an Anticancer Metabolite of Red Ginseng Extract Produced by Gut Microflora-Reference-Cited by-同舟云学术

Inhibition of P-Glycoprotein Leads to Improved Oral Bioavailability of Compound K, an Anticancer Metabolite of Red Ginseng Extract Produced by Gut Microflora

Published:2012-05-14 Issue:8 Volume:40 Page:1538-1544
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Yang Zhen,Wang Jing-Rong,Niu Tao,Gao Song,Yin Taijun,You Ming,Jiang Zhi-Hong,Hu Ming

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference36 articles.

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2. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng;Akao;J Pharm Pharmacol,1998

3. Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

4. Constitutive .BETA.-Glucosidases Hydrolyzing Ginsenoside Rb1 and Rb2 from Human Intestinal Bacteria.

5. Metabolism of Ginsenoside Re by Human Intestinal Microflora and Its Estrogenic Effect

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