Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy-Reference-Cited by-同舟云学术

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Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy

Published:2019-04-02 Issue:6 Volume:47 Page:648-656
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Pierrillas Philippe B.,Henin Emilie,Ball Kathryn,Ogier Julien,Amiel Magali,Kraus-Berthier Laurence,Chenel Marylore,Bouzom François,Tod Michel

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference50 articles.

1. Deciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo Observations

2. Bistability in Apoptosis: Roles of Bax, Bcl-2, and Mitochondrial Permeability Transition Pores

3. BDDCS Applied to Over 900 Drugs

4. Determination of Volume of Distribution at Steady State with Complete Consideration of the Kinetics of Protein and Tissue Binding in Linear Pharmacokinetics

5. Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

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