Three Faces of Mercaptopurine Cytotoxicity In Vitro: Methylation, Nucleotide Homeostasis, and Deoxythioguanosine in DNA

Author:

Coulthard Sally A.,McGarrity Sarah,Sahota Kalvin,Berry Philip,Redfern Chris P. F.ORCID

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference36 articles.

1. 6-Methylthioguanylic acid, a metabolite of 6-thioguanine

2. 6-Mercaptopurine: Cytotoxicity and biochemical pharmacology in human malignant T-lymphoblasts

3. Mechanism of thiopurine action;Coulthard;Assoc Med Bras,2012

4. Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients;Coulthard;J Chromatogr B Analyt Technol Biomed Life Sci,2016

5. Azathioprine with allopurinol: lower deoxythioguanosine in DNA and transcriptome changes indicate mechanistic differences to azathioprine alone;Coulthard,2017

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