Mechanistic Studies of the Cationic Binding Pocket of CYP2C9 In Vitro and In Silico: Metabolism of Nonionizable Analogs of Tienilic Acid-Reference-Cited by-同舟云学术

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Mechanistic Studies of the Cationic Binding Pocket of CYP2C9 In Vitro and In Silico: Metabolism of Nonionizable Analogs of Tienilic Acid

Published:2014-09-03 Issue:11 Volume:42 Page:1955-1963
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Tay Suzanne,Le Hoa,Ford Kevin A.,Nelson Sid D.,Khojasteh S. Cyrus,Rademacher Peter M.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference33 articles.

1. Total ban on tienilic acid;Beevers;Lancet,1980

2. Fulminant hepatitis due to tienilic acid;Biour;Lancet,1991

3. Opposite Behaviors of Reactive Metabolites of Tienilic Acid and Its Isomer toward Liver Proteins: Use of Specific Anti-Tienilic Acid−Protein Adduct Antibodies and the Possible Relationship with Different Hepatotoxic Effects of the Two Compounds

4. Metabolism of Tamoxifen by Recombinant Human Cytochrome P450 Enzymes: Formation of the 4-Hydroxy, 4′-Hydroxy andN-Desmethyl Metabolites and Isomerization oftrans-4-Hydroxytamoxifen

5. Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes

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1. Transitioning from Idiopathic to Explainable Autoimmune Hepatitis;Digestive Diseases and Sciences;2015-05-22

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