Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein–Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo-Reference-Cited by-同舟云学术

Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein–Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo

Published:2023-04-13 Issue:7 Volume:51 Page:851-861
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Zhang Yueping,Shipkova Petia A.,Warrack Bethanne M.,Nelson David M.,Wang Linna,Huo Runlan,Chen Jian,Panfen Erika,Chen Xue-Qing,Fancher R. Marcus,Ruan Qian,Christopher Lisa J.,Xue Yongjun,Sinz Michael,Shen Hong

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference51 articles.

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5. Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

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1. Ticagrelor modestly raises plasma riboflavin concentration in humans and inhibits riboflavin transport by BCRP and MRP4;Clinical Pharmacology & Therapeutics;2024-07-22

2. Brightening the Path: Riboflavin Illuminates Breast Cancer Resistance Protein Monitoring;Journal of Pharmacology and Experimental Therapeutics;2024-07-18

3. Expanding Role of Endogenous Biomarkers for Assessment of Transporter Activity in Drug Development: Current Applications and Future Horizon;Pharmaceutics;2024-06-25

4. Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters;Pharmaceutics;2024-05-10

5. A Pilot Study To Assess the Suitability of Riboflavin As a Surrogate Marker of Breast Cancer Resistance Protein in Healthy Participants;Journal of Pharmacology and Experimental Therapeutics;2024-01-31