Absorption, Metabolism, and Excretion of<sup>14</sup>C-Emvododstat Following Repeat Daily Oral Dose Administration in Human Volunteers Using a Combination of Microtracer Radioactivity and High-Radioactivity Doses-Reference-Cited by-同舟云学术

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Absorption, Metabolism, and Excretion of¹⁴C-Emvododstat Following Repeat Daily Oral Dose Administration in Human Volunteers Using a Combination of Microtracer Radioactivity and High-Radioactivity Doses

Published:2023-10-18 Issue:1 Volume:52 Page:26-34
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Ma Jiyuan,Laskin Oscar L.,Roffel Ad F.,Vaes Wouter H.J.,Tang Bowen,Kolnaar Jeroen,O’Keefe Kylie,Golden Lee,Kong Ronald^ORCID

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference17 articles.

1. Comparative Disposition and Metabolism of Paraherquamide in Sheep, Gerbils, and Dogs

2. Brief Report: A Phase 1b/Pharmacokinetic Trial of PTC299, a Novel PostTranscriptional VEGF Inhibitor, for AIDS-Related Kaposi’s Sarcoma: AIDS Malignancy Consortium Trial 059;Bender Ignacio;J Acquir Immune Defic Syndr,2016

3. Emvododstat, a potent dihydroorotate dehydrogenase inhibitor, is effective in preclinical models of acute myeloid leukemia;Branstrom;Front Oncol,2022

4. Discovery of novel small molecule inhibitors of VEGF expression in tumor cells using a cell-based high throughput screening platform;Cao;PLoS One,2016

5. Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

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