A Selective Orexin-1 Receptor Antagonist Attenuates Stress-Induced Hyperarousal without Hypnotic Effects

Author:

Bonaventure Pascal,Yun Sujin,Johnson Philip L.,Shekhar Anantha,Fitz Stephanie D.,Shireman Brock T.,Lebold Terry P.,Nepomuceno Diane,Lord Brian,Wennerholm Michelle,Shelton Jonathan,Carruthers Nicholas,Lovenberg Timothy,Dugovic Christine

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference44 articles.

1. Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local gaba which correlate with increases in heart rate

2. Alvaro G, Amantini D, Castiglioni E, Di Fabio R and Pavone F (2010) inventors, Glaxo Group Limited UK, assignee. N-{[(1S,4S,6S)-3-(2-Pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives as orexin receptor antagonists and their preparation and use for the treatment of diseases. WO2010063662A1

3. Hypocretin/orexin in arousal and stress

4. Neural Circuitry of Stress-Induced Insomnia in Rats

5. Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats

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