Preclinical Assessment of the Abuse Potential of Purified Botanical Cannabidiol: Self-Administration, Drug Discrimination, and Physical Dependence

Author:

Gray R.A.,Heal D.J.,Maguire D.R.,Gerak L.R.,Javors M.A.,Smith S.,France C.P.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference24 articles.

1. Arout CA Haney M Herrmann ES Bedi G Cooper ZD (2021) The dose‐dependent analgesic effects, abuse liability, safety and tolerability of oral cannabidiol in healthy humans. Br J Clin Pharmacol. Online ahead of print July 5, 2021. doi: 10.1111/bcp.14973.

2. Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers;Babalonis;Drug Alcohol Depend,2016

3. Cannabidiol: pharmacology and therapeutic targets;Britch;Psychopharmacology (Berl),2021

4. Center for Drug Evaluation and Research (CDER)/Food and Drug Administration (FDA) (2017) Guidance for Industry Assessment of Abuse Potential of Drugs. https://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm198650.pdf.

5. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

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