The Role of the Interchain Disulfide Bond in Governing the Pharmacological Actions of Botulinum Toxin-Reference-Cited by-同舟云学术

The Role of the Interchain Disulfide Bond in Governing the Pharmacological Actions of Botulinum Toxin

Published:2003-11-14 Issue:3 Volume:308 Page:857-864
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Simpson Lance L.,Maksymowych Andrew B.,Park Jong-Beak,Bora Roop S.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference20 articles.

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2. A common subunit structure in Clostridium botulinum type A, B and E toxins

3. A role for the interchain disulfide or its participating thiols in the internalization of botulinum neurotoxin A revealed by a toxin derivative that binds to ecto-acceptors and inhibits transmitter release intracellularly.

4. Herreros J, Lalli G, Montecucco C, and Schiavo G (1999) Pathophysiological properties of clostridial neurotoxins, in Comprehensive Sourcebook of Bacterial Protein Toxins (Alouf JE and Freer JH eds) pp 202–228, Academic Press, New York.

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