Targeting Signal Transducer and Activator of Transcription 3 Pathway by Cucurbitacin I Diminishes Self-Renewing and Radiochemoresistant Abilities in Thyroid Cancer-Derived CD133+ Cells

Author:

Tseng Ling-Ming,Huang Pin-I,Chen Yu-Rung,Chen Yu-Chih,Chou Yueh-Ching,Chen Yi-Wei,Chang Yuh-Lih,Hsu Han-Shui,Lan Yuan-Tzu,Chen Kuan-Hsuan,Chi Chin-Wen,Chiou Shih-Hwa,Yang De-Ming,Lee Chen-Hsen

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference41 articles.

1. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice;Blaskovich;Cancer Res,2003

2. IKK/NF‐κB and STAT3 pathways: central signalling hubs in inflammation‐mediated tumour promotion and metastasis

3. STATs in oncogenesis

4. Activation of STAT proteins and growth control

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