Apoptosis Induced by (E)-5-(2-Bromovinyl)-2′-deoxyuridine in Varicella Zoster Virus Thymidine Kinase-Expressing Cells Is Driven by Activation of c-Jun/Activator Protein-1 and Fas Ligand/Caspase-8

Author:

Tomicic Maja T.,Friedrichs Claudia,Christmann Markus,Wutzler Peter,Thust Rudolf,Kaina Bernd

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference43 articles.

1. On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.

2. Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.;Balzarini;Mol Pharmacol,1994

3. Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.;Balzarini;Mol Pharmacol,1985

4. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 and type 2 thymidine kinase gene.;Balzarini;Mol Pharmacol,1987

5. Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases

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