The Role of Lymphatic Transport on the Systemic Bioavailability of the Bcl-2 Protein Family Inhibitors Navitoclax (ABT-263) and ABT-199-Reference-Cited by-同舟云学术

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The Role of Lymphatic Transport on the Systemic Bioavailability of the Bcl-2 Protein Family Inhibitors Navitoclax (ABT-263) and ABT-199

Published:2013-11-08 Issue:2 Volume:42 Page:207-212
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Choo Edna F.,Boggs Jason,Zhu Chunqiang,Lubach Joseph W.,Catron Nathaniel D.,Jenkins Gary,Souers Andrew J.,Voorman Richard

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference25 articles.

1. Subversion of the Bcl-2 Life/Death Switch in Cancer Development and Therapy

2. The Bcl-2 family: roles in cell survival and oncogenesis

3. Davids MS, Roberts AW, Anderson MA, Pagel JM, Kahl BS, Gerecitano JF, Darden DE, Nolan CE, Gressick LA, Yang J et al. (2012) The BCL-2-specific BH3-mimetic ABT-199 (GDC-0199) is active and well-tolerated in patients with relapsed non-Hodgkin lymphoma: interim results of a phase I study (Abstract). 54th ASH Annual Meeting and Exposition; 2012 Dec 8–11; Atlanta, GA. Abstracts vol. 120, p 304, American Society of Hematology, Washington, DC.

4. Gershkovich P and Hoffman A (2005) Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability. Eur J Pharm Sci 26:394–404.

5. Gibaldi M Perrier D (1982) Pharmacokinetics, Marcel Dekker, New York.

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