Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance

Author:

Wood Francesca L.,Houston J. Brian,Hallifax David

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference54 articles.

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3. Effects of unstirred layers on membrane phenomena;Barry;Physiol Rev,1984

4. Bass L Pond SM (1988) Pharmacokinetics: Mathematical and Statistical Approaches to Metabolism and Distribution of Chemicals and Drugs ( Rescino A Pecile A eds) pp 241–265, Plenum, London.

5. Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man

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