Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver-Reference-Cited by-同舟云学术

Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver

Published:2022-10-02 Issue:12 Volume:50 Page:1493-1500
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Sharma Sheena,Ahire Deepak^ORCID,Basit Abdul,Lajoie Maria,Wang Christina,Lee Min S.,Blithe Diana L.,Amory John K.,Singh Dilip K.,Heyward Scott^ORCID,Prasad Bhagwat^ORCID

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference31 articles.

1. Ultrasensitive Quantification of Drug-metabolizing Enzymes and Transporters in Small Sample Volume by Microflow LC-MS/MS;Ahire;J Pharm Sci,2021

2. Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics;Al-Majdoub;Clin Pharmacol Ther,2021

3. Development of Novel Male Contraceptives;Amory;Clin Transl Sci,2020

4. Development of Dimethandrolone 17 -Undecanoate (DMAU) as an Oral Male Hormonal Contraceptive: Induction of Infertility and Recovery of Fertility in Adult Male Rabbits

5. Dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification of the Biotransformation Pathways of a Potential Oral Male Contraceptive, 11β-Methyl-19-Nortestosterone (11β-MNT) and Its Prodrugs: An In Vitro Study Highlights the Contribution of Polymorphic Intestinal UGT2B17;Pharmaceutics;2024-08-02

2. Male contraception: narrative review of ongoing research;Basic and Clinical Andrology;2023-11-09

3. Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with its Highly Variable Pharmacokinetics and Safety across Populations;Clinical Pharmacology & Therapeutics;2023-04-29