The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects-Reference-Cited by-同舟云学术

The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects

Published:2023-03-06 Issue:5 Volume:51 Page:599-609
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Amore Benny M.,Cramer Clay,MacDougall Diane,Emery Maurice G.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference25 articles.

1. Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers;Amore;Clin Transl Sci,2021

2. The effects of impaired hepatic function on pharmacokinetics of bempedoic acid, a first-in-class adenosine triphosphate (ATP) citrate lyase inhibitor, evaluated in an open-label, single-dose, parallel-group study (Abstract PIII-030);Amore;Clin Pharmacol Ther,2021

3. Pharmacokinetics of bempedoic acid in patients with renal impairment;Amore;Clin Transl Sci,2022

4. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

5. Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates;Chemical Society Reviews;2024

2. Fixed Combination for the Treatment of Dyslipidaemia;Current Atherosclerosis Reports;2023-09-16

3. Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance;Pharmacology & Therapeutics;2023-08

4. Phase 1, Single‐ and Multiple‐Ascending‐Dose, Food‐Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase;Clinical Pharmacology in Drug Development;2023-07-21

5. Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation;Pharmaceutics;2023-05-12