Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A<i>in vitro</i>-Reference-Cited by-同舟云学术

Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3Ain vitro

Published:2022-11-29 Issue:3 Volume:51 Page:293-305
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Paludetto Marie-Noëlle^ORCID,Kurkela Mika^ORCID,Kahma Helinä^ORCID,Backman Janne T.^ORCID,Niemi Mikko^ORCID,Filppula Anne M.^ORCID

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference46 articles.

1. Hematologic disposition of hydroxychloroquine enantiomers;Brocks;J Clin Pharmacol,1994

2. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood;Charlier;Biomed Chromatogr,2018

3. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC–ESI–MS/MS: An application for pharmacokinetic studies

4. Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation

5. Copeland R (2000) Modes of Reversible Inhibition, in Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis, pp 270–282, Wiley-VCH, New York.

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. From Drug Discovery to Drug Approval: A Comprehensive Review of the Pharmacogenomics Status Quo with a Special Focus on Egypt;Pharmaceuticals;2024-07-03

2. Identification of new risk factors for hydroxychloroquine and chloroquine retinopathy in systemic lupus erythematosus patients;Seminars in Arthritis and Rheumatism;2024-06

3. DeepP450: Predicting Human P450 Activities of Small Molecules by Integrating Pretrained Protein Language Model and Molecular Representation;Journal of Chemical Information and Modeling;2024-04-08

4. Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review;Drug Metabolism Reviews;2024-03-20

5. EIDD-1931 Treatment Tweaks CYP3A4 and CYP2C8 in Arthritic Rats to Expedite Drug Interaction: Implication in Oral Therapy of Molnupiravir;ACS Omega;2024-03-15