The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor-Reference-Cited by-同舟云学术

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The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor

Published:2023-07-31 Issue:10 Volume:51 Page:1332-1341
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Takahashi Ryan H.^ORCID,Malhi Vikram^ORCID,Liederer Bianca M.,Cho Sungjoon^ORCID,Deng Yuzhong,Dean Brian,Nugteren James,Yost Edward,Al-Sayah Mohammad A.,Sane Rucha,Kshirsagar Smita,Ma Shuguang,Musib Luna^ORCID

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference18 articles.

1. Perturbations of the AKT signaling pathway in human cancer

2. Determination of gdc-0068 and its metabolite in human plasma using high-performance liquid chromatography coupled to mass spectrometry. Abstracts from the 10th International Society for the Study of Xenobiotics ISSX meeting (abstract P6);Deng;Drug Metab Rev,2014

3. Accelerator Mass Spectrometry in Pharmaceutical Research and Development A New Ultrasensitive Analytical Method for Isotope Measurement

4. The genetic determinants of the CYP3A5 polymorphism

5. Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases;Ippen;Neuro-oncol,2019

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