Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A-Reference-Cited by-同舟云学术

Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A

Published:2022-02-13 Issue:5 Volume:50 Page:529-540
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Tang Lloyd Wei Tat,Wei Wan,Verma Ravi Kumar,Koh Siew Kwan,Zhou Lei,Fan Hao,Chan Eric Chun Yong

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

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3. Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant

4. THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE

5. Biotransformation and bioactivation reactions of alicyclic amines in drug molecules

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