An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Author:

Svensson Kjell A.,Heinz Beverly A.,Schaus John M.,Beck James P.,Hao Junliang,Krushinski Joseph H.,Reinhard Matthew R.,Cohen Michael P.,Hellman Sarah L.,Getman Brian G.,Wang Xushan,Menezes Michelle M.,Maren Deanna L.,Falcone Julie F.,Anderson Wesley H.,Wright Rebecca A.,Morin S. Michelle,Knopp Kelly L.,Adams Benjamin L.,Rogovoy Borys,Okun Ilya,Suter Todd M.,Statnick Michael A.,Gehlert Donald R.,Nelson David L.,Lucaites Virginia L.,Emkey Renee,DeLapp Neil W.,Wiernicki Todd R.,Cramer Jeffrey W.,Yang Charles R.,Bruns Robert F.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference31 articles.

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3. Beadle CD, Coates DA, Hao J, Krushinski JH, Reinhard MR, Schaus JM and Woldfangel CD (2014) inventors, Eli Lilly and Company, assignee. 3,4-dihydroisoquinolin-2(1H)-yl compounds. International patent WO 2014/193781 A1. 2014 May 5.

4. The Physiology, Signaling, and Pharmacology of Dopamine Receptors

5. Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes;Bruns;Mol Pharmacol,1990

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