PRD125, a Potent and Selective Inhibitor of Sterol O-Acyltransferase 2 Markedly Reduces Hepatic Cholesteryl Ester Accumulation and Improves Liver Function in Lysosomal Acid Lipase-Deficient Mice-Reference-Cited by-同舟云学术

PRD125, a Potent and Selective Inhibitor of Sterol O-Acyltransferase 2 Markedly Reduces Hepatic Cholesteryl Ester Accumulation and Improves Liver Function in Lysosomal Acid Lipase-Deficient Mice

Published:2015-08-17 Issue:2 Volume:355 Page:159-167
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Lopez Adam M.,Chuang Jen-Chieh,Posey Kenneth S.,Ohshiro Taichi,Tomoda Hiroshi,Rudel Lawrence L.,Turley Stephen D.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference48 articles.

1. Inhibition of Acyl-Coenzyme A:Cholesterol Acyltransferase 2 (ACAT2) Prevents Dietary Cholesterol-associated Steatosis by Enhancing Hepatic Triglyceride Mobilization

2. Hepatic entrapment of esterified cholesterol drives continual expansion of whole body sterol pool in lysosomal acid lipase-deficient mice

3. Clinical effect and safety profile of recombinant human lysosomal acid lipase in patients With cholesteryl ester storage disease

4. Cholesterol accumulation and liver cell death in mice with Niemann-Pick type C disease

5. ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase

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