Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia-Reference-Cited by-同舟云学术

Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

Published:2015-07-15 Issue:3 Volume:354 Page:471-482
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Bonaventure Pascal,Shelton Jonathan,Yun Sujin,Nepomuceno Diane,Sutton Steven,Aluisio Leah,Fraser Ian,Lord Brian,Shoblock James,Welty Natalie,Chaplan Sandra R.,Aguilar Zuleima,Halter Robin,Ndifor Anthony,Koudriakova Tatiana,Rizzolio Michele,Letavic Michael,Carruthers Nicholas I.,Lovenberg Timothy,Dugovic Christine

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference26 articles.

1. Promotion of sleep by targeting the orexin system in rats, dogs and humans

2. Narcolepsy in orexin Knockout Mice

3. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

4. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

5. Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat

Cited by 63 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Emerging therapies for treatment of agitation, psychosis, or apathy in Alzheimer’s disease;Expert Opinion on Emerging Drugs;2024-06-11

2. On the kinetic features of orexin receptor antagonists at orexin receptors, transduction systems and receptor binding;Medicine in Drug Discovery;2024-06

3. Discovery and first-time disclosure of CVN766, an exquisitely selective orexin 1 receptor antagonist;Bioorganic & Medicinal Chemistry Letters;2024-03

4. Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure–activity–relationship, and sleep-promoting properties in rats;RSC Medicinal Chemistry;2024

5. Emerging and upcoming therapies in insomnia;Translational and Clinical Pharmacology;2024